how might reduced enzyme function lead to disease?

1 Answer

  • When there is a mutation in a gene that produces an enzyme, it can cause disease. Phenylketonuria or PKU is a rare inherited disorder that causes the build up of phenylalanine. This can lead to brain damage in individuals with this disorder if they don't eat a very protein-- restricted diet. The gene mutation doesn't allow the creation of the enzymeneeded to break down Phenylalanine, an amino acid in proteins.   

    hope this helps